Domaine de l'Harmas was established in 2000 by Nathalie and her husband Patrick, starting with 5 hectares inherited from their mother's side of the family, making them the fourth generation of winemakers. Located north of the Châteauneuf-du-Pape appellation, the estate has gradually expanded to its current size of 23 hectares. In 2009, the estate converted to organic farming, achieving certification in 2012. The vineyard first expanded in 2010, and then again in 2014 with the arrival of their son Romuald, representing the fifth generation. The estate now produces Châteauneuf-du-Pape, Côtes du Rhône, Vin de Pays, and Vin de France wines. The first winery was built in 2000, expanded in 2012, and then further enhanced in 2023 with a new reception and storage building. The grape harvest is done by hand on some plots and by machine on others.